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We studied whether Parkinson's disease patients who had lost efficacy from pergolide(PERG)could benefit if transferred to bromocriptine(BCT)therapy. Using paired t-tests,we compared motor scores at baseline(when patients were still on PERG)and after 6 months of BCT therapy in 11 patients.No significant improvement occurred in any measure on BCT therapy(mean dose 33.6 mg/day),although patients remained stable.In 6 patients on whom"on/ off"data were obtained,decreased"off"time and increased"on"time without chorea occurred,but these changes were not statistically significant.The side effect profile was similar with the 2 drugs. |
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